Combining materials science, micro-/nano-technology, cellular and molecular biology and bioengineering, new diagnostic tools are developed to meet the point-of-care needs of achieving accurate diagnoses with high sensitivity and specificity. A very powerful tool for diagnosing and monitoring human diseases is microtechnology. Developing platforms based on microfluids that can precisely manipulate tiny body fluid volumes is helpful for diagnosis in a rapid and accurate manner. These platforms can be disposable, inexpensive, portable, and easy to use for the detection of human diseases. This class is designed to bridge the PDMS-based and paper-based microfluids microtechnology with biology and medicine, letting students learn by making a point-of-care diagnostic chip using paper-based device.