This course will focus on the recent advances in our understanding of the clinical features and pathogenesis of a wide range of neuropsychiatric disorders and neurological diseases, including Alzheimer’s disease, Parkinson’s disease, mood disorders, and Schizophrenia. Students will analyze research reports in which a range of proposed neurological and neuropsychiatric reports that may represent the underlying pathogenic mechanisms and potential treatments in these diseases. Topics link to the proposed cellular processes will include accumulation of aberrant proteins, protein misfolding, protofibril formation, ubiquitin-proteosomal pathway, autophagy, ER stress, axonal and dendritic transport, excitotoxic insult, and mitochondrial dysfunction in neurodegenerative diseases. Neuropharmacology studies of mood and thinking disorders are included. The course will especially emphasis and explore genetic and neuropharmacological contributions to these diseases, that has great advanced our understanding of our brains.