This course would cover advanced topics dealing with NEMS/MEMS technologies, transduction mechanisms (such as thermal, piezoresistive, capacitive, piezoelectric transduction), microfabricated sensors, and conditioning circuit design and measurement. In addition, the course also reviews different types of sensors for measurement and circuitry readouts of physical parameters such as acceleration, rotation rate, pressure. Three hands-on lab practicing will be offered to students using the Electronics Lab facility of iNEMS to provide students physical instrumentation on piezoresistive, capacitive, and piezoelectric transducers taught in the class, therefore benefiting their experimental skills. The design project is an important part of this course. It is carried out by each student or group who develops, simulates, and designs a device and testing configuration of his/her choice, and present the findings in a technical paper.